PAPER: Compounds that Inhibit Phytophthora ...

High-throughput chemical screening identifies compounds that inhibit different stages of the Phytophthora agathidicida and Phytophthora cinnamomi life cycles

July 2017

Lawrence SA, Armstrong CB, Patrick WM, Gerth ML 2017. High-throughput chemical screening identifies compounds that inhibit different stages of the Phytophthora agathidicida and Phytophthora cinnamomi life cycles. Front Microbiol 8: 1340.

ABSTRACT

Here, we have screened over 100 compounds for their anti-oomycete activity, as a potential first step toward identifying new control strategies. Our screening identified eight compounds that showed activity against both Phytophthora species. These included five antibiotics, two copper compounds and a quaternary ammonium cation. These compounds were tested for their inhibitory action against three stages of the Phytophthora life cycle: mycelial growth, zoospore germination, and zoospore motility.

KEYWORDS

oomycetes, Agathis australis, kauri dieback, avocado root rot, phenotype microarray, zoospore, high-throughput screening