PAPER: Male-harming mitochondrial haplotype
URL: https://doi.org/10.7554/elife.23551
Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies
May 2017
Wolff JN, Gemmell NJ, Tompkins DM, Dowling DK 2017. Introduction of a male-harming mitochondrial haplotype via 'Trojan Females' achieves population suppression in fruit flies. Elife 6.
ABSTRACT
Pests are a global threat to biodiversity, ecosystem function, and human health. Pest control approaches are thus numerous, but their implementation costly, damaging to non-target species, and ineffective at low population densities. The Trojan Female Technique (TFT) is a prospective self-perpetuating control technique that is species-specific and predicted to be effective at low densities. The goal of the TFT is to harness naturally occurring mutations in the mitochondrial genome that impair male fertility while having no effect on females. Here, we provide proof-of-concept for the TFT, by showing that introduction of a male fertility-impairing mtDNA haplotype into replicated populations of Drosophila melanogaster causes numerical population suppression, with the magnitude of effect positively correlated with its frequency at trial inception. Further development of the TFT could lead to establishing a control strategy that overcomes limitations of conventional approaches, with broad applicability to invertebrate and vertebrate species, to control environmental and economic pests.
KEYWORDS
paternal mtdna leakage; Drosophila melanogaster; pest-control; male-fertility transmission; evolution; fitness; consequences; maintenance; inheritance
There are no views created for this resource yet.
Additional Information
| Field | Value |
|---|---|
| Data last updated | unknown |
| Metadata last updated | 25 June 2024 |
| Created | unknown |
| Format | unknown |
| License | CC-BY-4.0 |
| Created | 2 years ago |
| Datastore active | False |
| Has views | False |
| Id | 9e95758d-0140-40d2-aa01-14d7ba53381f |
| Package id | 21c8852f-ab91-47f1-a0d2-98dac53969d8 |
| Position | 3 |
| State | active |